Table 5.

Univariate analyses of the impact of day 56 cell subsets on overall survival and relapse-free survival in (A) cell subsets included with median cut-off values and (B) cell subsets included as continuous (log₂-transformed) values, n = 104.

(A)
Cell subset	Overall survival		Relapse-free survival
	HR (95% CI)	P = value	HR (95% CI)	P = value
CD3
High	1.00		1.00
Low	2.18 (0.97–4.90)	0.06	1.15 (0.77–2.96)	0.23
CD4
High	1.00		1.00
Low	2.73 (1.15–6.48	0.02*	1.99 (0.99–4.00)	0.05*
CD8
High	1.00		1.00
Low	2.12 (0.94–4.76)	0.07	1.45 (0.74–2.84)	0.28
TCR γδ
High	1.00		1.00
Low	5.16 (1.94–13.7)	0.001**	2.70 (1.32–5.53)	0.007*
Vδ1
High	1.00		1.00
Low	2.26 (1.00–5.01)	0.05	2.20 (1.09–4.45)	0.03*
Vδ2
High	1.00		1.00
Low	5.02 (1.89–13.4)	0.001**	2.67 (1.30–5.50)	0.007*
NK
High	1.00		1.00
Low	1.55 (0.7–3.43)	0.28	1.98 (0.98–3.98)	0.06
CD16b
High	1.00		1.00
Low	1.96 (0.87–4.42)	0.11	1.35 (0.69–2.66)	0.38
CD16/56
High	1.00		1.00
Low	2.01 (0.89–4.54)	0.09	2.14 (1.06–4.32)	0.03*
CD56b
High	1.00		1.00
Low	2.31 (1.00–5.34)	0.05*	1.81 (0.91–3.61)	0.09
(B)
Cell subset, per doubling value	Overall survival		Relapse-free survival
	HR (95% CI)	P = value	HR (95% CI)	P = value
CD3	0.85 (0.64–1.42)	0.29	0.88 (0.67–1.14)	0.33
CD4	0.86 (0.64–1.16)	0.33	0.86 (0.67–1.12)	0.27
CD8	0.79 (0.59–1.05)	0.10	0.83 (0.65–1.07)	0.16
TCR γδ	0.63 (0.49–0.80)	<0.001**	0.76 (0.61–0.93)	0.008*
Vδ1	0.65 (0.44–0.96)	0.03*	0.81 (0.60–1.09)	0.16
Vδ2	0.65 (0.51–0.81)	<0.001**	0.75 (0.62–0.91)	0.003*
NK	0.75 (0.52–1.07)	0.11	0.81 (0.60–1.10)	0.18
CD16b	0.83 (0.63–1.09)	0.18	0.95 (0.75–1.19)	0.65
CD16/56	0.85 (0.60–1.18)	0.33	0.86 (0.6–1.13)	0.28
CD56b	0.61 (0.45–0.84)	0.002*	0.74 (0.56–0.97)	0.03*

Hazard ratios are of death in overall survival and of death or relapse in relapse-free survival. Cell subsets significant in multivariate analyses including adjustments for pre-transplant factors (conditioning therapy and donor age) are indicated by ^*,

^*p ≤ 0.05,

^**p ≤ 0.01. The italic values represent p-values equal to or below 0.05.