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. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889

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Copyright © 2019 Cariulo, Martufi, Verani, Azzollini, Bruni, Weiss, Deguire, Lashuel, Scaricamazza, Sancesario, Schirinzi, Mercuri, Sancesario, Caricasole and Petricca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Detection and quantification of pS129 SNCA and SNCA in human plasma using the Singulex assays. (A) Quantification of pS129 SNCA (i) and SNCA (ii) in 4 clinically obtained and 1 commercial sourced plasma samples. (iii) Table indicating measured values (pg/ml) of pS129 SNCA and SNCA in human plasma. (B) Specificity of SNCA and pS129 SNCA signals in plasma samples by immunodepletion with anti-SNCA mAb (S5566-Sigma) or with the unrelated GFAP mAb (G3893-Sigma). Means and SDs of 3 independent experiments. T-test (p < 0.05).