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. 2019 Aug 22;13:889. doi: 10.3389/fnins.2019.00889

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Copyright © 2019 Cariulo, Martufi, Verani, Azzollini, Bruni, Weiss, Deguire, Lashuel, Scaricamazza, Sancesario, Schirinzi, Mercuri, Sancesario, Caricasole and Petricca.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Analysis of matrix effects in pS129 SNCA and SNCA detection in human plasma and CSF. (A) Detection of spiked semisynthetic pS129 SNCA and SNCA proteins in two human clinical plasma and two CSF samples using SNCA Singulex assay. (i) Recovery of pS129 SNCA and SNCA proteins in human plasma and CSF samples is complete, as measured by SNCA Singulex assay. (ii) Table indicating means of recovery rates, SD and CV% of human plasma and CSF samples from two individuals. (B) Detection of spiked semisynthetic pS129 SNCA and SNCA proteins in two human clinical plasma and two CSF samples using pS129 SNCA Singulex assay. (i) Recovery of pS129 SNCA in human plasma is complete, while it is only partial in human CSF as measured by pS129 SNCA Singulex assay, indicating a matrix effect. Semisynthetic SNCA protein is not detected by pS129 SNCA Singulex assay as expected. (ii) Table indicating mean of recovery rates, SD and CV% of human plasma and CSF samples from two individuals.