Table 1.

Articles That Provided Definitions of Major and/or Minor surgery, and Categorized ≥3 Operations as Being Major and/or Minor in People With Hemophilia (n = 7).

Publication	Data Source	Surgery Category	No. of Procedures	Defining Criteria	Examples of Procedures in the Surgical Category
Auerswald et al12	Prospective single-center study	Major	23	Extraction of wisdom teeth and all other surgeries	None (other than wisdom teeth extraction)
		Minor	12	None	Adenectomy, dental surgeries (excluding wisdom tooth extraction)
Boadas et al8	Retrospective single-center study	Major	12	Any abdominal and orthopedic surgery	Pseudotumor removal/drainage/aspiration, inguinal hernia, achillotenotomy, resection of ear granuloma, reduction of fractured femur, wound debridement (finger), amputation (finger), Moore osteotomy, arthroscopic synovectomy, hip/knee debridement)
		Minor	3	Procedures requiring only skin excision or small sutures, synoviorthesis	Ureteral catheter insertion, cystoscopy and ureteral catheter removal, chemical synoviorthesis
Klukowska et al10	Pooled analysis of 5 prospective, open-label multicenter studies	Major	19	Require general or spinal anesthesia, opening into the great body cavities (with the possibility of severe hemorrhage requiring hemostatic therapy for at least 6 days), orthopedic interventions Involving joints (ankle, knee, hip, wrist, elbow, shoulder), third molar extraction or extraction of >3 teeth, and surgeries or conditions in which the participant’s life was at stake	None (other than those included within the definition)
		Minor	6	All other surgeries not fulfilling the major criteria were classed as minor	None
Lusher et al11	Prospective, multicenter surgery study	Major	37	Estimated to require daily treatment with FVIII concentrate for at least a week (no dosages provided)	Total knee replacement, joint fusion, hip replacement, synovectomy, other
		Minor	11	None	Central venous catheter devices, other
Powell et al13	Surgery subanalysis of a prospective, open-label, multicenter study	Major	14	Any elective or emergent surgical procedure that usually involves general anesthesia and/or respiratory assistance, in which a major body cavity is penetrated and exposed, or for which a substantial impairment of physical or physiological functions is produced	Knee replacements, knee/ankle arthroscopy, external fixation of knee, arm tendon transfer, closure of intestinal fistula, incision, and drainage of dental abscess with multiple extractions, incision and drainage of dental abscess and pilonidal cyst, debridement, fracture dislocation, amputations
		Minor	15	Any elective or emergent surgical procedure that does not involve general anesthesia and/or respiratory assistance	Dental extractions, ankle arthroscopic removal of osteophyte, PCI with stenting, coronary angiography, wart removal, biopsy of alleged paratonsillar abscess, dental crown, alveoplasties, root canal treatment
Santagostino et al14	Surgery subanalysis of 3 prospective, open-label, multicenter studies	Major	15	An invasive operative procedure where 1 or more of the following occurred: a body cavity was entered; a mesenchymal barrier was crossed; a fascial plane was opened; an organ was removed; normal anatomy was operatively altered	Synovectomy, arthroplasty (knee/hip), ankle arthroscopy, reduction of finger fracture, elbow radial head excision, panproctocolectomy, ileoanal pouch, circumcision
		Minor	26	An invasive operative procedure in which only skin, mucous membranes, or superficial connective tissue was manipulated	Dental, nail extirpation, central venous access device procedures, incision of periumbilical abscess, closure of fistula and debridement and pus drainage
Serban et al15	Observational, retrospective single-center study	Major	27	According to invasivenessa	Comminuted fracture reduction, displacement of the femur, thigh pseudotumor resection, bilateral shank and thigh amputation for pseudotumor, total hip arthroplasty, total knee arthroplasty, knee prosthesis, evacuation of compressive, giant hematomas (forearm, shank, or thigh)
		Minor	46	According to invasivenessa	Arthrocentesis, intra-articular administration of hyaluronic acid

^aInvasiveness not defined.