Table 1.
Baseline Characteristics of Patients.
| By Cohort | By Type of Treatment Administered | |||||
|---|---|---|---|---|---|---|
| Prophylactic Cohort, n = 40 | Treatment Cohort, n = 405 | PCC Alone, n = 244 | PCC and FFP, n = 128 | FFP Alone, n = 73 | All Patients, N = 445 | |
| Gender, n (%), N = 445 | ||||||
| Male | 20 (50.0) | 259 (64.0) | 149 (61.1) | 84 (65.6) | 46 (63.0) | 279 (62.7) |
| Female | 20 (50.0) | 146 (36.0) | 95 (38.9) | 44 (34.4) | 27 (37.0) | 166 (37.3) |
| Age, years, N = 445 | ||||||
| Mean (SD) | 59.0 (18.7) | 69.6 (13.3) | 69.4 (13.9) | 66.9 (15.8) | 69.1 (12.2) | 68.6 (14.2) |
| Height, cm, n = 418 | ||||||
| Mean (SD) | 166.7 (7.8) | 168.9 (10.9) | 168.2 (11.4) | 169.7 (10.3) | 168.6 (9.0) | 168.7 (10.7) |
| Weight, kg, N = 445 | ||||||
| Mean (SD) | 73.1 (18.8) | 77.1 (15.6) | 75.9 (16.0) | 78.8 (16.8) | 75.8 (14.3) | 76.7 (16.0) |
| Body mass index, kg/m2, n = 418 | ||||||
| Mean (SD) | 26.5 (7.0) | 27.0 (4.8) | 26.8 (5.0) | 27.6 (5.2) | 26.8 (4.5) | 27.0 (5.0) |
| Hemoglobin, g/dLa, n = 307 | ||||||
| Mean (SD) | 9.7 (2.5) | 9.4 (1.9) | 9.6 (1.8) | 9.1 (1.9) | 9.9 (2.7) | 9.5 (2.0) |
| Platelet count, ×109/La, n = 248 | ||||||
| Median (IQR) | 176 (65, 267) | 130 (98, 164) | 136 (102, 185) | 115 (86, 161) | 134 (106, 198) | 130 (96, 171) |
Abbreviations: FFP, fresh frozen plasma; IQR, interquartile range; PCC, prothrombin complex concentrate; SD, standard deviation
aMeasurement taken within 3 hours before study medication.