Table 4.

International Normalized Ratio (INR) Results.

	All Available Dataa			3 Hours Postdose vs Baseline–Data Only for Patients With Values at Both Time Points
Patients	Baseline	3 Hours Postdose	24 Hours Postdose	Change, Median (95% CI)	P Value
INR: Prophylactic cohort
Patients receiving PCC alone (n = 16)	1.7 (1.5-1.9), n = 14	1.4 (1.2-1.5), n = 10	1.5 (1.4-1.6), n = 11	−.3 (−.4 to −0.1) n = 10	.005
Patients receiving PCC & FFP (n = 5)	2.1 (1.8-3.0), n = 5	1.8 (1.6-2.4), n = 5	1.9 (1.6-2.2), n = 5	−.4 (−.8 to 0), n = 5	.06
Patients receiving FFP alone (n = 19)	1.7 (1.6-1.9), n = 13	1.4 (1.3-1.5), n = 15	1.4 (1.3-1.5), n = 11	−.3 (−.6 to −.2), n = 13	.001
INR: Treatment cohort
Patients receiving PCC alone (n = 228)	1.5 (1.3-1.7), n = 131	1.2 (1.2-1.2), n = 176	1.2 (1.1-1.3), n = 124	−.3 (−.4 to−.2), n = 96	<.001
Patients receiving PCC & FFP (n = 123)	1.6 (1.4-1.9) n = 62	1.2 (1.1-1.4), n = 90	1.2 (1.1-1.4) , n = 39	−.4 (−.5 to −.3), n = 49	<.001
Patients receiving FFP alone (n = 54)	1.4 (1.2–1.6), n = 27	1.2 (1.1-1.3), n = 36	1.2 (1.0-1.2), n = 40	−.3 (−.5 to .1), n = 14	.002

Abbreviations: CI, confidence interval; FFP, fresh frozen plasma; PCC, prothrombin complex concentrate.

^aData shown are median (interquartile range).