Table 2.
Parameters of APTT Waveform in Patients With Hemophilia With or Without Inhibitor, Those With VWD, and Healthy Volunteers.
| HV | Hemophilia | Hemophilia With Inhibitor | VWD | |
|---|---|---|---|---|
| Peak of acceleration | 35.5 (32.6-37.4) | 53.9a,b (44.1-66.5) | 112a,c (69.0-120) | 46.7b (32.5-59.5) |
| Height of acceleration-1 | 457 (411-535) | 237a,d (161-354) | 25.3a,e (20.9-33.5) | 397b,f (360-510) |
| Height of acceleration-2 | 224 (170-255) | 93.7a,d (57.2-167) | 5.01a,e (3.90-5.80) | 241b,c (176-257) |
| Width of acceleration-1 | 7.45 (6.80-8.00) | 20.0a,g (15.7-28.0) | 43.2a,f (23.1-88.7) | 13.4a,b (10.4-22.1) |
| Width of acceleration-2 | 17.7 (16.7-18.7) | 49.4a (35.0-195) | 210a (40.0-283) | 41.8a (35.6-300) |
| Peak of velocity | 38.7 (36.3-40.8) | 64.9a,b (52.2-85.0) | 154.3a,c (83.8-219) | 52.4b (36.8-72.4) |
| Height of velocity | 183 (144-200) | 155d (113-217) | 27.9a,e (24.7-50.7) | 209b,f,h (182-485) |
| Width of velocity | 19.5 (18.0-20.3) | 64.0a (50.1-100) | 234a (52.9-316) | 52.0a (43.4-100) |
| Peak of ½ fibrin formation | 40.9 (37.8-42.7) | 66.2a,b (54.4-104) | 159a,c (118-223) | 53.8b (37.9-73.7) |
| Height of ½ fibrin formation | 242 (207-306) | 443a (296-578) | 502i (252-870) | 302 (182-336) |
Abbreviations: APTT, activated partial thromboplastin time; HV, healthy volunteers; VWD, von Willebrand disease.
a P< .001 compared with HV.
b P < .01 compared with hemophilia with inhibitor.
c P < .01 compared with hemophilia.
d P < .001 compared with hemophilia with inhibitor.
e P < .001 compared with hemophilia.
f P < .05 compared with hemophilia.
g P < .05 compared with hemophilia with inhibitor.
h P < .05 compared with HV.
i P < .01 compared with HV.