Table 3.
Day 0, Day 4, and Day 8 Ang-2 Levels Listed by Mortality Outcome (Left) and DIC Severity (Right).
| Ang-2 Levels, ng/mL: Day 0, Day 4, Day 8 | All | Survivors, n = 86 | Non-survivors, n = 15 | a P | Sepsis, n = 20 | Sepsis + Non-overt DIC, n = 58 | Sepsis + Overt DIC, n = 24 | b P |
|---|---|---|---|---|---|---|---|---|
| Healthy Controls | ||||||||
| n (%) | 50 | – | – | – | – | – | – | – |
| Mean ± SEM | 1.9 ± 0.2 | – | – | – | – | – | – | – |
| Median (range) | 1.6 (0.5-5.5) | |||||||
| Day 0 patients | ||||||||
| n (%) | c101 | 86 (85.1) | 15 (14.9) | – | 20 (19.6) | 58 (56.9) | 24 (23.5) | – |
| Mean ± SEM | 15.2 ± 1.9 | 12.5 ± 1.5 | 30.2 ± 8.6 | 0.0010 | 8.3 ± 2.5 | 11.7 ± 1.4 | 29.4 ± 6.3 | – |
| Median (range) | 8.3 (0.7-136.3) | 7.4 (0.7-66.2) | 19.3 (1.8-136.3) | – | 5.8 (1.0-53.6) | 8.3 (0.7-44.2) | 17.6 (1.8-136.3) | 0.0003 |
| Day 4 patients | ||||||||
| n (%) | 55 | 45 (81.8) | 10 (18.2) | – | 10 (17.9) | 36 (64.2) | 10 (17.9) | – |
| Mean ± SEM | 7.3 ± 1.1 | 6.7 ± 1.2 | 9.8 ± 2.1 | 0.0819 | 4.7 ± 1.0 | 7.9 ± 1.5 | 7.8 ± 2.3 | – |
| Median (range) | 5.7 (0.1-53.2) | 4.4 (0.1-53.2) | 9.4 (1.3-24.5) | – | 4.4 (0.1-11.3) | 6.8 (0.4-53.2) | 6.7 (1.6-24.5) | 0.5494 |
| Day 8 patients | ||||||||
| n (%) | 30 | 24 (80) | 6 (20) | – | 8 (26.7) | 22 (73.3) | 0 | – |
| Mean ± SEM | 8.5 ± 2.1 | 7.6 ± 2.5 | 11.7 ± 4.1 | 0.2264 | 2.2 ± 0.3 | 10.8 ± 2.7 | – | – |
| Median (range) | 4.9 (0.5-61.0) | 3.2 (0.9-61.0) | 11.0 (0.5-26.9) | – | 2.0 (1.1-3.2) | 8.2 (0.5-61.0) | – | – |
Abbreviations: Ang-2, Angiopoietin-2; DIC, disseminated intravascular coagulation; SEM, standard error of the mean.
a P is a Mann-Whitney t test between means of survivors and nonsurvivors.
b P is a Kruskal-Wallis 1-way ANOVA for medians of DIC severity groups.
c Mortality data, but not DIC severity data, was missing for 1 patient; therefore, n = 101 for baseline mortality data and n = 102 for baseline DIC severity data.