FIG 4.

CCR5⁺ CD4⁺ T cells significantly decreased during SHIV.CH505 infection. CD4⁺ T cell subsets expressing CCR5 were characterized in rectum, colon, and lymph node tissue of SHIV.CH505-infected rhesus macaques by flow cytometry. (A) Percentage of CCR5⁺ cells of CD4⁺ T cells in rectum, colon, and lymph node at all time points. (B) Percentage of CCR5⁺ cells of CD4⁺ central memory T cells in rectum, colon, and lymph node at all time points. (C) Percentage of CCR5⁺ cells of CD4⁺ effector memory T cells in rectum, colon, and lymph node at all time points. (D) Percentage of CCR5⁺ cells of CD4⁺ transitional memory T cells in rectum, colon, and lymph node at all time points. In all panels, each animal is represented by a different symbol. Statistical significance between post-SHIV infection time points and pre-SHIV infection baseline was calculated using Friedman’s test and Dunn’s multiple-comparison test.