FIG 9.

Significant increase in Ki-67⁺ CD8⁺ T cells in SHIV.CH505 infection. CD8⁺ T cell subsets expressing Ki-67 were characterized in rectum, colon, and lymph node tissue of SHIV.CH505-infected rhesus macaques by flow cytometry. (A) Percentage of Ki-67⁺ cells of CD8⁺ T cells in rectum, colon, and lymph node at all time points. (B) Percentage of Ki-67⁺ cells of CD8⁺ central memory T cells in rectum, colon, and lymph node at all time points. (C) Percentage of Ki-67⁺ cells of CD8⁺ effector memory T cells in rectum, colon, and lymph node at all time points. (D) Percentage of Ki-67⁺ cells of CD8⁺ transitional memory T cells in rectum, colon, and lymph node at all time points. In all panels, each animal is represented by a different symbol. Statistical significance between post-SHIV infection time points and pre-SHIV infection baseline was calculated using Friedman’s test and Dunn’s multiple-comparison test.