FIG 6.

PGG exerts an anti-RABV function in an miR-455-5p/SOCS3/STAT3-dependent fashion. BHK-21 cells were given different treatments, including PGG, CVS, or miR-455-5p mimic and inhibitor transfection, alone or in combination. (A) The CVS P mRNA level was detected by qRT-PCR. (B) Viral titers were examined by DFA. (C) BHK-21 cells were given different treatments, including PGG, CVS, or si-SOCS3 or Flag-STAT3 transfection, alone or in combination, and then SOCS3/STAT3 (P/T) protein and CVS P protein levels were detected by Western blotting. (D, E) The CVS P mRNA level and viral titers were detected, respectively, by qRT-PCR and DFA. *, P < 0.05; **, P < 0.01.