FIG 4.

ART promotes transient intestinal bacterial instability in the stool microbiome of healthy rhesus macaques. (A to C) Unweighted UniFrac, weighted UniFrac, and Bray-Curtis measures, as indicated, of beta diversity by PCoA for individual PR inhibitor-treated animals across time (A), individual control animals across time (B), and individual animals at baseline (C, color-coded by treatment group). (D) Instability indices comparing beta-diversity measures (as in panel C) across individual time points. Significance was assessed by two-way unpaired t test, one-way ANOVA, or PERMANOVA, as indicated.