FIG 8.

ZAP isoforms exhibit differential activities against HBV. HepG2 cells were cotransfected with ZAP-expressing constructs and pHBV1.3x, and secreted HBeAg (A) and HBsAg (B) levels in the supernatant were measured. Mean values for quadruplicate wells are plotted; error bars represent the SD. Asterisks indicate statistically significant differences (**, P < 0.01; ***, P < 0.001; ****, P < 0.0001 [by one-way ANOVA and Dunnett’s multiple-comparison test]). The data are representative of results from 3 independent experiments.