FIG 7.

Cxcr2 ablation increases the numbers of mature oligodendrocytes in JHMV-infected mice. JHMV-infected Cxcr2-CKO mice were treated with vehicle or tamoxifen, and at day 28 p.i. the animals were sacrificed and the spinal cords were removed. Representative NG2 (A, B) and GST-π (D, E) staining in control (n = 5) and tamoxifen-treated (n = 4) mice is shown. Quantification reveals reduced numbers of NG2-positive cells in tamoxifen-treated mice (C) and increased numbers of dual-positive GST-π-positive cells in tamoxifen-treated mice (F) compared to vehicle-treated mice. Data represent those from 2 independent experiments, and significance was measured using an unpaired 2-tailed Student's t test. **, P < 0.01; ***, P < 0.001. DAPI, 4′,6-diamidino-2-phenylindole.