FIG 2.

Immune-mediated control of a persistent viral infection. (A) NSE-CD46⁺, NSE-CD46⁺ perforin KO, and NSE-CD46⁺ IFN-γ KO mice were challenged i.c. with 1 × 10⁴ PFU of MV Edmonston. Mice were monitored daily. Percent survival is indicated. Data represent at least 2 individual experiments using NSE-CD46⁺, NSE-CD46⁺ perforin KO, and NSE-CD46⁺ IFN-γ KO mice. (B and C) RNA was collected from whole-brain tissue of mice of the indicated genotypes. RT-qPCR data were generated using random-hexamer priming for cDNA generation, followed by qPCR using primers specific for the MV nucleoprotein and cyclophilin B as a standard. Data were analyzed using the ΔΔC_T method. #, P < 0.05, Mann-Whitney U test of NSE-CD46⁺ controls compared to immunodeficient mice.