FIG 9.

Marginal predictions of antibody concentration dynamics from the model (in log₁₀ scale). Marginal predictions show the effect of covariates on antibody concentration dynamics. The dark red plain line (Europe Ad26/MVA D57 group) differs from the dark blue plain line (Europe MVA/Ad26 D57) only by order of immunizations, showing that MVA/Ad26 order implies a higher peak of antibody concentrations than the Ad26/MVA order. The dark red plain line (Europe Ad26/MVA D57 group) differs from light red plain line (Europe Ad26/MVA D29) only by interval between prime and boost immunizations, showing that a boost at day 56 induces a higher peak of antibody concentrations than a boost at day 28. Finally, the dark red plain line (Europe Ad26/MVA D57 group) differs from the dark red dashed line (East Africa Ad26/MVA D57 group) only by geographic region, showing that European subjects have a similar antibody peak as East African ones but higher sustained antibody concentrations. For all curves, light dashed lines correspond to 95% confidence intervals accounting for the uncertainty on parameters estimation.