Figure 3.

Algorithm for the use of factor concentrates and neuroimaging for newborns with hemophilia. *If a newborn is born to a hemophilia carrier or possible carrier, but a diagnosis of hemophilia was not obtained antenatally, the newborn should be presumed to be affected and appropriate care provided until postnatal testing confirms that the newborn is not affected. The dashed pathways indicate that if, at any time and regardless of the events of birth, a newborn develops concerning symptoms or has bleeding that is observed either clinically or with imaging, the prompt administration of replacement factor is the priority, followed by appropriate investigation. CT indicates computed tomography; neuro, neurological; NICU, neonatal intensive care unit; MRI, magnetic resonance imaging; US, ultrasound.