Table 1.

Anticancer Properties of Tinzaparin Sodium.

Study	Model	Target	Effect	Process
Stevenson et al59	Mice	P- and L-selectin	Inhibition	Metastasis
Schlesinger et al60	Mice	VLA-4–VCAM-1	Inhibition	Metastasis
Harvey et al61	Hamster ovarian cells and human breast cancer cells	CXCR4–CXCL12	Inhibition	Metastasis
Alyahya et al62	Mice	E-cadherin	Upregulation	Metastasis
Bauer et al63	Mice	von Willebrand factor	Downregulation	Metastasis
Amirkhosravi et al64	Mice	TFPI	Upregulation	Metastasis
Mousa and Mohamed65	Chick chorioallantoic membrane model	TFPI	Upregulation	Angiogenesis
Mousa and Mohamed66	Human umbilical vein endothelial cells	TFPI	Upregulation	Angiogenesis
Pfankuchen et al67	Human ovarian cancer cells	Cell surface proteoglycans	Transcriptional reprogramming	Chemoresistance

Abbreviations: CXCL12, C-X-C motif chemokine ligand 12; CXCR4, C-X-C chemokine receptor type 4; TFPI, tissue factor pathway inhibitor; VCAM-1, vascular cell adhesion molecule-1; VLA-4, very late antigen-4.