Table 2.
Parameters of the APTT Wave Form in Patients With Various Diseases.
| HVs | Hemophilia | Inhibitor | aPL | Warfarin | Anti-Xa | PW | TP | DIC | |||
|---|---|---|---|---|---|---|---|---|---|---|---|
| Second derivative | Peak 1 | Time (second) | 35.5 (32.6-37.4) | 58.1 (43.4-6.0) | 69.0 (62.0-117.2) | 64.8 (45.8-73.3) | 34.8 (32.5-46.3) | 48.0 (42.7-54.3) | 30.9 (29.4-34.7) | 34.7 (31.0-37.7) | 61.9 (42.4-98.9) |
| Height (mAbs/s2) | 457 (411-535) | 242 (127-405) | 24.5 (15.3-32.1) | 161 (116-396) | 523 (247-625) | 323 (263-344) | 791 (586-1015) | 549 (481-671) | 139 (74.2-444) | ||
| Wide (second) | 7.45 (6.80-8.00) | 20.4 (10.3-24.8) | 24.2 (18.4-74.8) | 22.5 (15.8-29.3) | 7.30 (6.90-14.0) | 11.4 (10.4-13.0) | 7.70 (7.15-8.90) | 7.65 (7.20-7.90) | 12.7 (9.70-23.8) | ||
| Peak 2 | Height, mAbs/s2 | 224 (170-255) | 94.2 (54.1-204) | 4.60 (3.78-5.58) | 72.9 (40.8-109) | 107 (81.2-150) | 278 (220-315) | 426 (289-574) | 180 (120-433) | 52.8 (26.0-198) | |
| Wide, second | 17.7 (16.7-18.7) | 57.1 (35.0-95.0) | 100 (57.5-185) | 44.1 (34.4-75.0) | 45.6 (29.9-60.3) | 36.9 (32.1-40.9) | 23.2 (19.7-25.4) | 24.4 (22.1-60.3) | 47.9 (40.1-73.4) | ||
| First derivative | Time, second | 38.7 (36.2-40.8) | 71.4 (49.3-84.7) | 142 (72.9-220) | 79.1 (52.4-56.6) | 37.2 (35.1-51.1) | 42.0 (37.7-48.1) | 34.7 (33.2-37.1) | 37.7 (34.2-40.5) | 69.9 (50.2-111) | |
| Height, mAbs/s | 183 (144-200) | 156 (117-221) | 24.7 (19.4-38.2) | 151 (119-209) | 197 (164-213) | 622 (483-677) | 326 (220-404) | 199 (183-317) | 107 (66.5-283) | ||
| Wide, second | 19.5 (18.0-20.3) | 52.9 (34.4-88.8) | 174 (74.6-272) | 51.0 (33.1-66.4) | 49.3 (39.2-60.7) | 45.4 (40.9-51.9) | 26.8 (19.6-30.2) | 30.3 (26.2-60.3) | 57.6 (47.0-86.5) | ||
| Fibrin formation | Height, mAbs | 328 (286-431) | 492 (430-592) | 528 (373-663) | 570 (483-633) | 478 (452-498) | 575 (495-674) | 426 (322-488) | 411 (383-464) | 424 (277-665) | |
| 1/2 height, second | 40.9 (37.8-42.7) | 71.0 (49.8-87.7) | 146 (110-226) | 81.2 (58.2-88.3) | 44.2 (39.1-61.2) | 50.2 (44.8-56.4) | 36.5 (35.0-38.5) | 41.8 (37.4-47.9) | 70.5 (50.8-119) | ||
| Number | 30 | 11 | 5 | 12 | 10 | 18 | 12 | 6 | 20 | ||
Abbreviations: Anti-Xa, patients treated with anti-Xa agent; aPL, patients positive anti-phospholipid antibody; DIC, disseminated intravascular coagulation; HVs, healthy volunteers; mAbs, m-absorbance; PW, pregnant women; TP, thrombophilia; warfarin, patients treated with warfarin.