Table 1.

Relative Neutralization of the Direct Anti-Xa Agents by Andexanet Alfa on Thrombin Generation.

Peak Thrombin
Drug	Apixaban		Betrixaban		Edoxaban		Rivaroxaban
	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa
0	137.68	172.51	137.68	172.51	137.68	172.51	137.68	172.51
0.062	107.8	174.05	89.08	168.9	95.89	170.09	77.36	168.08
0.125	84.99	169.58	63.3	177.81	49.55	178.37	58.96	169.71
0.25	52.2	172.87	50.7	181.41	49.48	168.13	38.63	170.02
0.5	35.18	175.57	38.31	175.82	34.82	171.98	25.74	172.82
1.0	24.26	168.56	29.56	172.83	25.9	166.17	17.14	179.49
Area Under the Curve (AUC)
Drug	Apixaban		Betrixaban		Edoxaban		Rivaroxaban
	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa
0	705.82	797.36	705.82	797.36	705.82	797.36	705.82	797.36
0.062	713.25	777.92	699.49	760.2	731.17	779.04	676.22	735.77
0.125	675.34	760.15	642.91	798.83	621.97	801.83	658.58	738.15
0.25	610.72	778.22	619.74	791.91	634.58	762.26	598.63	771.24
0.5	540.46	786.11	580.93	777.88	538.05	784.11	516.84	762.39
1.0	487.07	812.8	535.49	804.72	492.4	790.3	434.14	842.85
Lag Time
Drug	Apixaban		Betrixaban		Edoxaban		Rivaroxaban
	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa	Saline	Andexxa
0	2.29	1.95	2.29	1.95	2.29	1.95	2.29	1.95
0.062	2.96	2.29	3.63	2.29	3.79	2.29	3.29	2.29
0.125	3.29	2.12	4.46	2.29	5.47	2.29	3.96	2.12
0.25	4.13	2.29	5.13	2.29	5.47	2.29	4.96	2.29
0.5	4.63	2.29	6.3	2.29	6.3	2.29	5.97	2.29
1.0	5.63	2.29	8.14	2.29	8.81	2.46	7.81	2.29