Table 2.
Molecular Weight and Potency of Ovine Heparin Sodium and Ovine Enoxaparin Sodium.
| Lot# | Ovine Heparin Sodium | HP std | Ovine Enoxaparin Sodium | LMWH std | ||||
|---|---|---|---|---|---|---|---|---|
| 80-ALR-089 | 80-ALR-092 | OES-404A | Medefil Hep | OES-401D | OES-402D | OES-403D | Lovenox | |
| MW (Da) | ||||||||
| MW (UV) | 13 624 | 13 558 | 14 459 | 18 853 | 3778 | 3761 | 3820 | 4026 |
| MW (RI) | 13 407 | 13 499 | 14 299 | 18 856 | 4245 | 4192 | 4274 | 4486 |
| Mn (UV) | 10 113 | 10 025 | 10 772 | 14 781 | 3260 | 3242 | 3311 | 3403 |
| Mn (RI) | 9794 | 9762 | 10 525 | 15 405 | 3725 | 3686 | 3739 | 3823 |
| USP potency | ||||||||
| Xa (U/mg) | 201 | 196 | 205 | 190 | 105 | 103 | 118 | 107 |
| IIa (U/mg) | 201 | 193 | 201 | 191 | 42 | 41 | 43 | 39 |
| Xa/IIa ratio | 1.00 | 1.02 | 1.02 | 0.99 | 2.5 | 2.5 | 2.7 | 2.7 |
Abbreviations: MW, molecular weight; RI, refractive index.