TABLE 1.
Differences between Preadmission Users and Nonusers of Gabapentinoidsa
| Gabapentinoid Preadmission Users (n = 550b) | Gabapentinoid Nonusers (n = 3,553) | |
|---|---|---|
| Demographics | ||
| Age, median (IQR), years | 71 (60-82) | 72 (57-82) |
| Female | 254 (46.2) | 1,620 (45.6) |
| Pregabalin | 408 (74.2) | - |
| Gabapentin | 144 (26.2) | - |
|
| ||
| Comorbidities | ||
| Hypertensionc | 346 (62.9) | 1,880 (52.9) |
| Diabetesc | 220 (40) | 969 (27.3) |
| Receiving insulinc | 96 (43.6) | 239 (24.7) |
| Hemoglobin A1c, median (IQR); (n = 241) | 7.6 (6.8-9.2) | 7.3 (6.1-8.6) |
| Coronary artery diseased | 136 (24.7) | 664 (18.7) |
| Peripheral vascular diseasec | 61 (11.1) | 127 (3.6) |
| Congestive heart failured | 84 (15.3) | 383 (10.8) |
| Atrial fibrillationd | 124 (22.5) | 634 (17.8) |
| CHADS2 score, median (IQR) | 2 (1-3) | 2 (1-3) |
| Previous strokee | 77 (14) | 369 (10.4) |
| Stage IV/V chronic kidney disease | 75 (17.1) | 402 (14.8) |
| Chronic obstructive pulmonary diseased | 96 (17.5) | 443 (12.5) |
| Active cancer | 109 (19.8) | 684 (19.3) |
| Ever smoker (n = 3,470) | 262 (56.3) | 1,528 (50.8) |
|
| ||
| Other medications | ||
| Hypnotics, excluding benzodiazepinesd | 41 (7.5) | 127 (3.6) |
| Benzodiazepinesd | 135 (24.5) | 509 (14.3) |
| Opioidsd | 155 (28.2) | 426 (12) |
| Benzodiazepines and opiatesd | 56 (10.2) | 127 (3.6) |
| Proton pump inhibitord | 315 (57.3) | 1,341 (37.7) |
|
| ||
| Prescriptions (n = 3,621 discharged alive) | ||
| Home users continued at discharge | 430 (86.9) | - |
| Home users deprescribed at discharge | 65 (13.1) | - |
| Home users with dose decrease at discharge without further plan to taper | 33 (6.7) | - |
| New users during admission | - | 45 (1.4) |
|
| ||
| Outcomes | ||
| Length of stay, median (IQR)e | 6 (3-14) | 6 (3-13) |
| Inpatient death | 55 (10) | 427 (12) |
a
All data are given as number (percentage) unless otherwise indicated.
b
Includes two patients receiving both gabapentionoids preadmission.
c
P < .001;
d
P < .01;
e
P < .05.
Abbreviation: IQR, interquartile range