Table 3. Baseline characteristics of the population associated with conversion to new onset diabetes and with prediabetes reversion, survival approach—Multivariate Cox analysis.

	Multivariate Cox analysis
	Before selection		After stepwise selection†
	HR [95% CI]	p-value	HR [95% CI]	p-value
Study of conversion to new onset diabetes (135 events/383)
Age (+1 SD)	0.93 [0.77; 1.12]	0.43	-	-
Sex (Women/men)	0.90 [0.60; 1.34]	0.59	-	-
Diabetes risk score (+1 SD)	1.35 [1.08; 1.68]**	0.0081	1.31 [1.07; 1.60]**	0.0089
Hypertension (y/n)	1.00 [0.67; 1.47]	0.98	-	-
Statin therapy (y/n)	0.92 [0.61; 1.40]	0.71	-	-
Fasting plasma glucose (+1 SD)	1.47 [1.23; 1.75]***	<0.0001	1.46 [1.23; 1.74]***	<0.0001
HbA1c (+1 SD)	1.54 [1.26; 1.88]***	<0.0001	1.52 [1.25; 1.84]***	<0.0001
Fatty Liver Index (+1 SD)	1.28 [1.03; 1.58]*	0.024	1.31 [1.07; 1.61]**	0.008
	Before selection		After stepwise selection†
Study of prediabetes reversion (265 events/383)	HR [95% CI]	p-value	HR [95% CI]	p-value
Age (+1 SD)	0.93 [0.81; 1.06]	0.29	-	-
Sex (Women/men)	1.22 [0.91; 1.65]	0.19	-	-
Diabetes risk score (+1 SD)	0.88 [0.76; 1.03]	0.11	-	-
Hypertension (y/n)	1.13 [0.85; 1.51]	0.40	-	-
Statin therapy (y/n)	1.02 [0.74; 1.41]	0.89	-	-
Fasting plasma glucose (+1 SD)	0.75 [0.66; 0.86]***	<0.0001	0.75 [0.66; 0.86]***	<0.0001
HbA1c (+1 SD)	0.79 [0.68; 0.90]***	0.00063	0.79 [0.69; 0.90]***	0.0003
Fatty Liver Index (+1 SD)	0.89 [0.77; 1.03]	0.11	0.85 [0.75; 0.96]**	0.0077

^†Considered candidates for multivariate adjusted Cox model were defined as follows: baseline fasting plasma glucose and Fatty liver index were “forced” in the model; age, sex, diabetes risk score, hypertension, statin therapy, HbA_1c were candidates. Multivariate Fractional Polynomial approach was also considered, but no polynomial transformation was proposed for a threshold selection value = 0.20

* p <0.05;

** p < 0.01;

*** p < 0.001