Table 1. Antimicrobial classes, antimicrobial agents, concentration ranges, and susceptibility breakpoints for Campylobacter isolates.
Antimicrobial Class |
Antimicrobial Agent | Concentration Range (μg/mL) | MIC Interpretive Standard (μg/mL)A | |
---|---|---|---|---|
Susceptible | Resistant | |||
Aminoglycosides | Gentamicin | 0.12–32 | ≤2 | ≥4 |
Ketolides | Telithromycin | 0.015–8 | ≤4 | ≥8 |
Lincosamides | Clindamycin | 0.03–16 | ≤2 | ≥4 |
Macrolides | Azithromycin | 0.015–64 | ≤2 | ≥4 |
Erythromycin | 0.03–64 | ≤8 | ≥16 | |
Phenicols | Florfenicol | 0.03–64 | ≤4 | N/A |
Quinolones | Ciprofloxacin | 0.015–64 | ≤1 | ≥2 |
Nalidixic acid | 4–64 | ≤16 | ≥32 | |
Tetracyclines | Tetracycline | 0.06–64 | ≤4 | ≥8 |
AIsolates were tested for antimicrobial susceptibility using an automated broth microdilution technique (Sensititre®). Minimum inhibitory concentration (MIC) interpretive standards of the Canadian Integrated Program for Antimicrobial Resistance Surveillance (for most antimicrobials) [15] or the Centers for Disease Control and Prevention (for telithromycin) [25] were used to classify isolates as susceptible or resistant (resistant plus intermediate).