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. 2019 Aug 29;14(8):e0221938. doi: 10.1371/journal.pone.0221938

Table 4. KOG enrichment analysis of DEGs compared with the transcriptome.

The up-regulated DEGs in [Ca2+] 10 mM relative to [Ca2+] 0 mM were analyzed.

KOG functional cluster DEG frequency of use Transcriptome frequency of use P-value Q-value
Secondary metabolites biosynthesis, transport, and catabolism 23 of 353 (6.52%) 265 of 10692 (2.48%) 7.16E-06 1.86E-04
Signal transduction mechanisms 55 of 353 (15.58%) 1062 of 10692 (9.93%) 2.60E-04 0.007
Extracellular structures 4 of 353 (1.13%) 43 of 10692 (0.40%) 0.013 0.341
Lipid transport and metabolism 29 of 353 (8.22%) 613 of 10692 (5.73%) 0.020 0.512
Inorganic ion transport and metabolism 11 of 353 (3.12%) 242 of 10692 (2.26%) 0.105 1
Cell wall/membrane/envelope biogenesis 12 of 353 (3.40%) 278 of 10692 (2.60%) 0.131 1
Defense mechanisms 4 of 353 (1.13%) 86 of 10692 (0.80%) 0.155 1
Chromatin structure and dynamics 8 of 353 (2.27%) 214 of 10692 (2.00%) 0.276 1
Intracellular trafficking, secretion, and vesicular transport 14 of 353 (3.97%) 402 of 10692 (3.76%) 0.350 1
Translation, ribosomal structure and biogenesis 17 of 353 (4.82%) 503 of 10692 (4.70%) 0.396 1
General function prediction only 51 of 353 (14.45%) 1537 of 10692 (14.38%) 0.447 1
Cytoskeleton 8 of 353 (2.27%) 254 of 10692 (2.38%) 0.463 1
Carbohydrate transport and metabolism 14 of 353 (3.97%) 439 of 10692 (4.11%) 0.484 1
Function unknown 20 of 353 (5.67%) 655 of 10692 (6.13%) 0.589 1
Energy production and conversion 12 of 353 (3.40%) 415 of 10692 (3.88%) 0.618 1
Cell cycle control, cell division, chromosome partitioning 3 of 353 (0.85%) 131 of 10692 (1.23%) 0.633 1
Amino acid transport and metabolism 14 of 353 (3.97%) 488 of 10692 (4.56%) 0.651 1
Transcription 11 of 353 (3.12%) 435 of 10692 (4.07%) 0.779 1
Nucleotide transport and metabolism 2 of 353 (0.57%) 141 of 10692 (1.32%) 0.849 1
Coenzyme transport and metabolism 2 of 353 (0.57%) 156 of 10692 (1.46%) 0.893 1
Posttranslational modification, protein turnover, chaperones 35 of 353 (9.92%) 1362 of 10692 (12.74%) 1 1
Replication, recombination, and repair 2 of 353 (0.57%) 388 of 10692 (3.63%) 1 1
RNA processing and modification 2 of 353 (0.57%) 564 of 10692 (5.27%) 1 1