TABLE 3. Changes in the number and percentage of opioid deaths co-occurring with benzodiazepines, cocaine, and methamphetamine, by type of opioids involved in death — 25 states,* State Unintentional Drug Overdose Reporting System (SUDORS), July–December 2017 to January–June 2018.

Type of opioid involved in death	No. of opioid deaths with co-occurring drugs (%)
	Benzodiazepines†	Cocaine†	Methamphetamine†	None of the three drugs
All opioids§	−264 (−5.7)¶	−106 (−2.3)	206 (14.6)¶	−437 (−8.0)¶
Any IMF**	256 (11.3)¶	445 (14.0)¶	241 (31.0)¶	217 (6.7)¶
Illicit opioid, no IMF††	−389 (−39.0)¶	−514 (−42.9)¶	−69 (−14.7)¶	−537 (−43.3)¶
Prescription opioid, no illicit opioid§§	−131 (−9.7)¶	−37 (−12.2)	34 (20.5)	−117 (−12.0)¶

Abbreviation: IMF = illicitly manufactured fentanyl.

* Alaska, Connecticut, Delaware, Florida, Georgia, Illinois, Kentucky, Maine, Massachusetts, Minnesota, Missouri, Nevada, New Jersey, New Mexico, North Carolina, Ohio, Oklahoma, Pennsylvania, Rhode Island, Tennessee, Utah, Vermont, Virginia, Washington, and Wisconsin.

^† Opioid deaths co-occurring with benzodiazepines, cocaine and methamphetamine are not mutually exclusive as deaths associated with multiple nonopioids (e.g., cocaine and benzodiazepines) will be counted in both categories.

^§ All opioid deaths (N = 13,415 during January–June 2018).

^¶ Statistically significant change from July–December 2017 to January–June 2018 based on z-tests or nonoverlapping confidence intervals if the number of deaths was <100 (p<0.05).

** All opioid deaths where IMF was involved (N = 9,105 during January–June 2018).

^†† All deaths involving other illicit opioids (heroin, fentanyl analogs, and U-series) where IMF was not involved (N = 2,019 during January–June 2018).

^§§ Deaths involving prescription opioids without illicit opioid involvement (N = 2,291 deaths during January–June 2018).