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. Author manuscript; available in PMC: 2019 Aug 29.
Published in final edited form as: Dev Cell. 2015 Feb 23;32(4):447–458. doi: 10.1016/j.devcel.2015.01.016

Figure 1. Extrinsic and intrinsic cues regulate the oligodendrocyte program.

Figure 1.

Progression through the oligodendrocyte lineage is mediated by numerous factors. As highlighted, signaling from the extracellular matrix (sub-figure adapted from Bauer et al., 2009) is critical in modulating the dynamic cytoskeletal reorganization of the premyelinating-myelinating oligodendrocyte transition. Additionally, signal transduction through the Akt/mTOR pathway, modified by PTEN, has been shown to be a regulator of myelin biogenesis. It should be noted that the ERK1/2 signaling pathway is also involved in regulating CNS myelination (Ishii et al., 2012), but this figure focuses on the Akt/mTOR pathway investigated in Snaidero et al. (2014).