TABLE 5.

Strategies for improving tolerability of topical agents

DOSING AND TITRATION	FORMULATION AND ADJUNCTIVE AGENTS
Initiating low dose therapy	Use of cream and nonalcohol-based vehicles, when possible
	Concomitant use of moisturizer
	Use of gentle cleansing agents
Initiating every-other-day dosing with titration upward slowly as needed Level 4, D, GPP	Avoid astringents and toners
	Avoid overly drying soaps and cleansers
	Level 4, D, GPP