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. 2019 Aug 5;129(9):3670–3685. doi: 10.1172/JCI123700

Figure 4. 4F treatment improves the inflammatory mediator profile of mouse intestinal tissue and plasma.

Figure 4

*P < 0.05; **P < 0.01; ***P < 0.001. (A–E) The effect of 4F on the intestinal and plasma lipid mediator profile of Cox2-MKO (MKO) and FLOX mice fed chow or CCHF for 8.5 weeks was determined by LC-MS/MS (n = 5–7/group). Heatmaps of lipid mediator changes in intestine (A) and plasma (B) are shown. Significant reductions of intestinal proinflammatory LOX (C) and plasma proinflammatory LOX (D) and COX (D) mediators. Tt, total. Statistical analyses were conducted using the Benjamini-Hochberg procedure applied to 1-way ANOVA for each lipidomic analyte with FDR at level α = 0.05, followed by Tukey’s multiple comparisons test with adjusted P values.