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. 2019 Aug 12;129(9):3839–3851. doi: 10.1172/JCI128382

Figure 6. Crystal structure of scFv9 in complex with P[4] VP8*.

Figure 6

(A) The overall structure of scFv9 in complex with P[4] VP8*. The scFv9 heavy chain (VH) and light chain (VL) are colored in blue and light blue, respectively. P[4] VP8* is shown in gold. The β-sheets and C-terminal α-helix of VP8* are labeled. (B) The footprint of scFv9 on P[4] VP8*. The surface of VP8 is shown with 60% transparency, and the antibody binding residues are shown as stick models. (C–E) Molecular interactions between P[4] VP8* and CDRs of scFv9. The proteins are colored as in A. The interacting residues of P[4] VP8* and scFv9 are represented with stick models and are labeled. The hydrogen bonds and electrostatic interactions are shown using dashed black lines.