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. 2019 Aug 8;6(5):e598. doi: 10.1212/NXI.0000000000000598

Figure 1. Serum and CSF neurofilament levels following Immunoablative Autologous Haematopoietic Stem Cell Transplant.

Figure 1

Baseline NfL levels (n = 23) were significantly elevated relative to controls (n=33) in (A), serum (p = 0.0001, 95% CI 13.33-32.38) and (B), CSF (p = 0.0001, 95% CI 1122-2638 ). Following IAHSCT, levels significantly reduced in both compartments (serum p=0.0023, 95% CI 6.39-26.94; CSF p = 0.0068, 95% CI 522.0-2141). Post-ASCT NfL levels (12 and 36m) in both serum and CSF were not significantly different from controls (p ≥ 0.05). Serum and CSF NfL levels were c, correlated (p = 0.0001, Spearman r = 0.76). 12m: 12 months post IAHSCT. 36m: 36 months post IAHSCT. Error bars represent the standard error of the mean. CI = confidence interval; IAHSCT = immunoablation followed by autologous hematopoietic stem cell transplantation; NfL = neurofilament light chain.