TABLE 1.
Simulated body fluid mineral coatings on aliphatic polyester scaffolds
| Reference | SBF magnificationa | Base material | Coating period | Cell type | Scaffold structure | Additional treatment | Major result |
|---|---|---|---|---|---|---|---|
| Choong, Triffitt, & Cui (2004) | 1.5x | PCL | 14 days | hMSC | FDM 3D | NaOH pretreatment, SiO2 pretreatment | Deposited mineral structure and ion ratios are similar to hydroxyapatite. Coating improved biological response in vitro and in vivo |
| Oyane et al. (2005) | 1x | PCL | 24 hr | None | FDM 3D, film | O2 plasma pretreatment, ion dipping pretreatment | SBF treatment achieved formation of a bone-like apatite layer on PCL scaffolds |
| Oyane et al. (2005) | lx | PCL | 24 hr | None | FDM 3D, film | NaOH pretreatment, ion dipping pretreatment | SBF treatment achieved formation of a bone-like apatite layer on PCL scaffolds |
| Jiao, Liu, Cui, & Zhou (2007) | lx | PLLA | 7, 14, 21 days | None | Porogen-leached 3D, film | NaOH pretreatment | Hydrolysis pretreatment quantitatively increases precipitation from SBF solution |
| F. Yang, Wolke, & Jansen (2008) | 10x, lx | PCL | 2–6 hr | None | Electrospun fiber mesh, film | Argon plasma pretreatment | 6 hr 10x SBF incubation lost all porous structure |
| Beşkardeş & Gümüşderelioğlu (2009) | 10x | PCL | 6, 24 hr | MC3T3 | Film | None | 6- and 24-hr coating periods with SBF affect cell proliferation and osteogenesis |
| Mavis, Demirtaş, Gümüşderelioğlu, Gündüz, & Çolak (2009) | 10x | PCL | 2, 4, 6, 15 hr | MC3T3 | Electrospun fiber mesh | None | Changes in phosphate and carbonate concentrations removed the need for pretreatments |
| Suárez-González et al. 2011) | 2x | PCL | 7 days | None | SLS 3D | NaOH pretreatment, VEGF and BMP2 adsorption posttreatment | SBF-coated scaffolds bound BMP2 and VEGF, promoting sustained growth factor release |
| Choi & Murphy (2012) | 2–5x | PLGA | 2 days (2x) + 4 days (2–5x) |
hMSC | Film | NaOH pretreatment | SBF ion ratio and concentration variations created distinctive morphological regimes affecting cell response. |
| J. H. Lee et al. (2014) | 2x, 1x | PCL | 4 days (2x) + 2 days (lx) | rMSC | PCL-gelatin blend fiber mesh | FN-OCN fusion protein adsorption posttreatment | Advanced biointerfacial system improved stem cell adhesion and osteogenic differentiation |
Abbreviations: BMP2, bone morphogenetic protein-2; FDM 3D, fused deposition modeling three-dimensional scaffold; FN-OCN, fibronectin-osteocalcin fusion protein; hMSC, human mesenchymal stem cell; MC3T3, mouse calvaria osteoblast precursor cell line; NaOH, sodium hydroxide, O2, oxygen; PCL, poly(ε-caprolactone); PLGA, poly (lactic acid-co-glycolic acid); PLLA, poly(L-lactic acid); rMSC, rat-derived primary mesenchymal stem cells; SBF, simulated body fluid; SiO2, silicon dioxide; VEGF, vascular endothelial growth factor.
a
Fold change in concentration of SBF components from original physiological formulation