Table 1. Diagnostic Performance of NLV Value and Estimated Fat Fraction at MRS in Detection of Varying Degrees of Hepatic Steatosis.
| Degree of Hepatic Steatosis | Cut-Off Value | AUC | Sensitivity (%) | Specificity (%) | PPV (%) | NPV (%) | Accuracy (%) |
|---|---|---|---|---|---|---|---|
| NLV value | |||||||
| ≥ Mild (≥ 5%) | ≤ 1.21 | 0.953 (0.835–0.995) | 100.0 (89.1–100.0) | 87.5 (47.3–99.7) | 97.0 (83.6–99.5) | 100.0 | 97.5 (39/40) |
| ≥ Moderate (> 33%) | ≤ 1.19 | 0.896 (0.758–0.970) | 96.4 (81.7–99.9) | 66.7 (34.9–90.1) | 87.1 (75.1–93.8) | 88.9 (52.8–98.3) | 87.5 (35/40) |
| Severe (> 66%) | ≤ 1.12 | 0.735 (0.572–0.862) | 59.1 (36.4–79.3) | 83.3 (58.6–96.4) | 81.3 (59.3–92.8) | 62.5 (49.1–74.2) | 70.0 (28/40) |
| Fat fraction at MRS | |||||||
| ≥ Mild (≥ 5%) | > 8.01 | 0.973 (0.865–0.999) | 87.5 (71.0–96.5) | 100.0 (63.1–100.0) | 100.0 | 66.7 (44.4–83.3) | 90.0 (36/40) |
| ≥ Moderate (> 33%) | > 8.01 | 0.982 (0.880–1.000) | 96.4 (81.7–99.9) | 91.7 (61.5–99.8) | 96.4 (80.5–99.4) | 91.7 (61.4–98.7) | 95.0 (38/40) |
| Severe (> 66%) | > 16.93 | 0.970 (0.860–0.999) | 86.4 (65.1–97.1) | 100.0 (81.5–100.0) | 100.0 | 85.7 (67.7–94.5) | 92.5 (37/40) |
Numbers in parentheses are 95% CIs. AUC = area under receiver operating characteristic curve, CI = confidence interval, MRS = magnetic resonance spectroscopy, NLV = normalized local variance, NPV = negative predictive value, PPV = positive predictive value