Table 1.

Effects of doxorubicin (Dox), with or without ibudilast on skeletal muscles in C57BL/6 mice

Tissue ratio	Dox(−) vehicle (N = 7)	Dox(−) ibudilast (N = 7)	Dox(+) vehicle (N = 7)	Dox(+) ibudilast (N = 7)
GM/TL (mg·mm−1)	8.4 ± 0.3	8.5 ± 0.3	7.0 ± 0.2*	8.0 ± 0.2#
GM/BW (mg·g−1)	6.1 ± 0.2	6.6 ± 0.2	6.0 ± 0.2	6.5 ± 0.2
SOL/TL (mg·mm−1)	0.64 ± 0.03	0.68 ± 0.04	0.52 ± 0.04*	0.62 ± 0.03
SOL/BW (mg·g−1)	0.47 ± 0.02	0.53 ± 0.03	0.45 ± 0.03	0.50 ± 0.02
EDL/TL (mg·mm−1)	0.78 ± 0.04	0.76 ± 0.03	0.61 ± 0.01*	0.71 ± 0.04
EDL/BW (mg·g−1)	0.57 ± 0.03	0.59 ± 0.03	0.52 ± 0.02	0.57 ± 0.03

Tissue ratios are as follows: GM/TL; gastrocnemius weight/tibial length, GM/BW; gastrocnemius weight / body weight, SOL/TL; soleus weight / tibial length, SOL/BW; soleus weight / body weight, EDL/TL; extensor digitorum longus weight / tibial length, EDL/BW; extensor digitorum longus weight / body weight. Data are shown as the mean ± SEM.

^* P < .05, significantly different from Dox(−) vehicle.

^# P < .05, significantly different from Dox(+) vehicle; two‐way ANOVA followed Sidak's comparison test.