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. 2019 Aug 29;10:3902. doi: 10.1038/s41467-019-11845-y

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Validation of differentially methylated CpGs between clusters. Differentially methylated CpGs between clusters were validated in an external dataset (19) a cluster S1 vs M. b cluster S2 vs S1 c cluster S2 vs M. Difference in CpG beta values for differentially methylated sites in CLUES data on x axis and corresponding delta beta value for CpG in validation data on y axis. Green color indicates significant association with cluster in validation dataset (FDR < 0.1)