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. 2019 Aug 29;9:12562. doi: 10.1038/s41598-019-48840-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Serum antibody titers to viral antigens, as measured by ELISA, depend on the virus entry receptor and whether the patient has endometriosis. In endometriosis group (E) the titers are rarely increased against viruses binding to heparan sulfate (HPV16, HSV1, CMV), whereas in Endometriosis-free (N) group the titers are higher (* - q < 0.05). Titers against viruses binding sialic acid receptors (Echovirus and Bocavirus) are not significantly different between the groups. (A) HPV16-E6, p = 0.0064, FDRq = 0.0346; (B) HPV155-L1, p = 0.0012, FDRq = 0.0270; (C) HPV19-L1, p = 0.0096, FDRq = 0.0346; (D) HSV1, p = 0.01, FDRq = 0.0346; (E) CMV (HHV5), p = 0.018, FDRq = 0.0436; (F) VZV, p = 0.08, FDRq = 0.0685; (G) human polyomavirus 7 (HPyV7), p = 0.013, FDRq = 0.0388; (H) Echovirus VP1, p = 0.64, FDRq = 0.3697; and (I) Human bocavirus (HBoV) VP1, p = 0.94, FDRq = 0.4867 (Student’s two-tailed t-test, E (n = 9) vs. N (n = 16)).