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. 2019 Aug 29;9:12587. doi: 10.1038/s41598-019-49028-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Quantification of FNP intensity along the spinal column following IT injection. (A) Exponential curve fits of FNP intensity along the spinal column showed relatively constant decay in FNP signal moving caudally down the spinal cord at all time points. (B) AUC of the curve fits for individual mice at each time point (n = 3/time point) shows FNP delivery to the spinal cord trended upwards over time and was significantly higher at 3 weeks compared to 6, 24 and 48 hours (p < 0.05, 1-way ANOVA with Bonferroni’s Multiple Comparison Test). Mean ± SD shown.