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. 2019 Aug 29;9:12587. doi: 10.1038/s41598-019-49028-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representative confocal images of FNP distribution around the brain. FNPs (red) were distributed around the entire brain and could be seen following the meninges into the sulci of the cerebellum. There was a strong preference for ventral distribution and consistently high delivery to the supracerebellar cistern (C) and pituitary recess (P). Clearance of FNPs across the cribriform plate into the nasal mucosa (N) was seen at all time points. Qualitatively, a general decrease in total FNP intensity was observed over time, consistent with IVIS data. Linear corrections were applied equally across images to better show FNP distribution. Cell nuclei (DAPI) are in blue to show the gross anatomy of the brain. Images without DAPI, to better see FNP signal, can be found in the Supplementary data. Scale bar = 500 µm.