Table 1.
Functional and structural parameters of mice at study end.
| n | Akita−/− Ren−/− | Akita−/− Ren+/− | Akita+/− Ren−/− | Akita+/− Ren+/− |
|---|---|---|---|---|
| 16 | 10 | 6 | 4 | |
| Phenotype | Non-diabetic, Normotensive |
Non-diabetic, Hypertensive |
Diabetic, Normotensive |
Diabetic, Hypertensive |
|
Plasma glucose (mmol/L) |
9.1 ± 0.6 | 8.8 ± 0.7 | 30.2 ± 1.4a,b | 29.0 ± 1.6a,b |
| HbA1c (%) | 5.1 ± 0.1 | 4.9 ± 0.1 | 13.4 ± 0.4a,b | 13.0 ± 0.0a,b |
| Body weight (g) | 44.2 ± 1.5 | 40.8 ± 1.1 | 35.8 ± 1.7a | 34.2 ± 0.9a,b |
|
Systolic blood pressure (mm Hg) |
100 ± 4 | 151 ± 5a | 99 ± 9b | 145 ± 14a,c |
|
Serum creatinine (μmol/L) |
32.9 ± 2.3 | 35.8 ± 4.2 | 58.8 ± 4.8a,b | 70.2 ± 3.1a,b |
|
24 hour urine volume (mL) |
2.2 ± 0.7 | 2.8 ± 0.8 | 51.0 ± 6.4a,b | 33.2 ± 2.6a,b,c |
|
Right kidney weight (μg) |
245 ± 10 | 290 ± 20 | 492 ± 54a,b | 445 ± 43a,b |
| Tibia length (mm) | 19.9 ± 0.4 | 19.1 ± 0.6 | 18.5 ± 0.6 | 18.2 ± 0.6 |
|
Right kidney/tibia length (μg/mm) |
12.3 ± 0.4 | 15.2 ± 1.0 | 27.0 ± 3.8a,b | 24.4 ± 2.2a,b |
|
Right kidney/body weight (μg/g) |
5.6 ± 0.2 | 7.2 ± 0.6 | 13.7 ± 1.4a,b | 13.0 ± 1.4a,b |
ap < 0.05 vs. Akita−/− Ren−/−. bp < 0.05 vs. Akita−/− Ren+/−. cp < 0.05 vs. Akita+/− Ren−/−. Data are presented as mean +/− standard error of the mean.