Fig. 7.

IniA-mediated isoniazid resistance in M. smegmatis. a Growth curves of wild-type M. smegmatis [Ms (WT)] and iniA-deleted strain [Ms (ΔiniA::hyg)] in the presence or absence of 20 μg mL⁻¹ isoniazid. b Growth curves of Ms (ΔiniA::hyg) with overexpression of wild-type IniA (S9::iniA) in 20 μg mL⁻¹ isoniazid, compared with no antibiotics or no IniA overexpression. c As shown in (b), overexpression of mutant IniA, including S50A/R63A, ΔHB2, R488D, and Δ480–492. Each bar is the mean and SD of three measurements. The source data of Fig. 7a–c are provided in the Source Data file