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. 2019 Aug 29;9:12540. doi: 10.1038/s41598-019-49021-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Isogenic cell panels expressing individual ADAM15 wildtype and catalytically inactive isoforms in MDA-MB-231 and MCF-7 cells. (a) Schematic representation of ADAM15 ICD variants. Proline-rich regions are boxed. (b) Expression of ADAM15 isoforms in MDA-MB-231 cells, (c) MDA/ADAM15 C and D cells treated with 50 µM Decitabine for 72hrs, each 24 hr replacing the media and adding Decitabine fresh. For the last 24hrs, 500 nM Trichostatin A was added, followed by analysis for ADAM15 expression. (d) Expression level of ADAM15 isoforms in MCF-7 cells.