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. 2019 Aug 29;10:3892. doi: 10.1038/s41467-019-11905-3

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — Correlations of DNA methylation and gene expression profiles between Egr1KO and Tet1KO frontal cortices. Methylation correlations (a) and gene expression correlations (b) between Egr1KO and Tet1KO mice. c Aberrant DNA methylation on Galnt9 and Npas4 loci. Each CpG is represented by a circle; yellow in circles indicates the percentage of methylation in each CpG site. The statistical significance of methylation differences between Egr1/Tet1KO and WT mice was evaluated with the Wilcoxon rank-sum test. d The correlations between DNA methylation levels of Galnt9, Npas4 loci and corresponding gene expression during brain development from embryonic day 11.5 (E11.5) (denoted in blue color) to 22 months (22 mo) (denoted in red color)