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. 2019 Aug 29;9:12514. doi: 10.1038/s41598-019-48973-w

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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(A) Representative images of p62 immunostaining of samples from SHRSP5/Dmcr rats fed control and HFC diets for 2 and 8 weeks. Arrows indicate the accumulation in the cytoplasm of enlarged hepatocytes. Scale bar 100 μm. (B) Representative images of ubiquitin immunostaining of samples from rats fed control and HFC diets for 8 weeks. Scale bar 100 μm.