Figure 2.

Formation of the solubilising drug–cyclodextrin nanoparticle. The cyclodextrin molecules, which are frequently referred to as host molecules, are displayed as a cup-like structure, which initially forms a complex with individual host molecules. The host shown here represents an idealised dexamethasone molecule. At higher concentrations, drug–cyclodextrin complexes aggregate to form larger nanoparticles that can be administered topically to the eye.