Figure 2.
ABCA1 KO elevates both ENaC P O and the number of active ENaC (N) in the patch. (a) Representative single‐channel recordings of ENaC activity from cell‐attached patches in control and ABCA1 KO mouse with or without lovastatin treatment. Downward events show ENaC openings. Vpipette = +40 mV. (b–d) Summary data of ENaC P O (b), channel density (c), and NP O, which is N times P O (d); n is shown at the base of each bar. *P < .05, # P < .05, & P < .05, significantly different as indicated; one‐way ANOVA followed by Bonferroni post hoc test. Summary data of total ENaC activity, number of active ENaC, and ENaC open probability are shown in Table 1