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. 2019 Jul 30;176(18):3695–3711. doi: 10.1111/bph.14775

Figure 7.

Figure 7

ABCA1 KO reduces ciliary length and reduces luminal ATP release. (A) Confocal images of kidney slices of either control or ABCA1 KO mice. Cilia were labelled with an anti‐acetylated α‐tubulin antibody shown in green. Scale bars: 10 μm. (b) Summary data of cilia length (the numbers of cilia from six separate experiments in each group were used for analysis: control mice group: 290 cilia from nine mice; control mice treated with lovastatin group: n = 82 cilia from five mice; ABCA1 KO mice group: n = 264 cilia from eight mice; and ABCA1 KO mice treated with lovastatin group: n = 83 cilia from five mice. Cilia in ABCA1 KO mice were stunted. *P < .05, # P < .05, & P < .05; significantly different as indicated; one‐way ANOVA followed by Bonferroni post hoc test. (c) Summary data of urinary ATP from control and ABCA1 KO mice with or without lovastatin treatment. *P < .05, # P < .05, & P < .05; significantly different as indicated; one‐way ANOVA followed by Bonferroni post hoc test