Table 1.

ENaC functional studies in split‐open CCD in WT and ABCA1 KO mice

Group	ENaC activity, NPo	ENaC open probability, Po	Number of active ENaC, N
Control mice	0.56 ± 0.12	0.19 ± 0.03	2.80 ± 0.44
ABCA1 KO mice	2.33 ± 0.56*	0.44 ± 0.06*	5.00 ± 0.79*
Control mice + Lovastatin	0.24 ± 0.08&	0.12 ± 0.04	2.00 ± 0.24
ABCA1 KO mice + Lovastatin	0.38 ± 0.09 #	0.16 ± 0.02 #	2.40 ± 0.42 #

Data presented are means ± SEM. Summary of total ENaC activity (NP _O), the number of active ENaC, (N), and ENaC open probability (P _O) in control mice and ABCA1 KO mice after 2 weeks of infusion with lovastatin.

^* P < .05, significantly different from control mice.

^# P < .05, significantly different from ABCA1 KO mice.

^& P < .05, significantly different from control mice.