Figure 5.

The elimination of ATP‐derived formation of extracellular adenosine abrogates 6‐OHDA‐induced dopaminergic neurodegeneration in the striatum and nigra. Representative coronal sections of the dorsolateral striatum (a) or substantia nigra (c) stained TH from saline‐treated rats and 6‐OHDA‐treated rats without or with the CD73 inhibitor α,β‐methylene ADP (AOPCP, 100 μM continuous intracerebroventricular infusion). Immunohistochemical quantification of TH density in the striatum (b) or substantia nigra (d). The data are means ± SEM (n = 6). *P < .05, significantly different from saline; ^# P < .05, significantly different from 6‐OHDA; one‐way ANOVA with Newman–Keuls post hoc test