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. 2019 Oct;127:427–435. doi: 10.1016/j.bone.2019.07.011

Fig. 4.

Fig. 4

Bone strength and cortical vascularity.

(A) Representative load displacement curves from 3-point bend testing of tibias from male P70 WT and Pyy KO mice. Graphs show yield, maximum and fracture loads, stiffness and energy dissipated prior to fracture (toughness) (mean ± SEM, n = 7–8 per genotype, *P < 0.05, **P < 0.01, ***P < 0.001 versus WT; unpaired t-test).

(B) BSE-SEM images of mid-femur endosteal surfaces from male P70 WT and Pyy KO male mice; scale bar = 200 μm. Graphs show endosteal surface vessel density and relative frequency histogram of vessel size (mean ± SEM, n = 4 per genotype, **P < 0.01 versus WT; unpaired t-test).

(C) Representative load displacement curves from 3-point bend testing of tibias from male P186 WT and Pyy KO mice. Graphs show yield, maximum and fracture loads, stiffness and energy dissipated prior to fracture (toughness) (mean ± SEM, n = 7–8 per genotype, *P < 0.05, **P < 0.01, versus WT; unpaired t-test).

(D) BSE-SEM images of mid-femur endosteal surfaces from female P186 WT and Pyy KO mice; scale bar = 200 μm. Graphs show endosteal surface vessel density and relative frequency histogram of vessel size (mean ± SEM, n = 4 per genotype, ***P < 0.001 versus WT; Kolmogorov-Smirnov test).