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. 2019 Aug 29;9:12569. doi: 10.1038/s41598-019-48991-8

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© The Author(s) 2019

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Transcriptional deregulation of genes involved in stem cell function. RNA-Seq was performed on sorted LSK cells from 3 Oga^Vav-Cre and 3 wildtype mice. Genomatix analysis called 41 significantly downregulated and 12 significantly upregulated genes represented as a heatmap (using RPKMs) (a) and volcano plot (b). (b) Oga was excluded from volcano plot for scale, genes with a log2(foldchange) ± >1.25 and p < 0.005 are labelled. (c) Top 10 enriched gene ontology terms (GO) among the deregulated genes as determined by Genomatix. (d) Representative IGV view of the most significantly down regulated (Fgf3) and upregulated (Slc1a5) genes.